The tribulations of stroke trials.

Amphetamine trials and tribulations.

BACKGROUND Laboratory experiments conducted since the 1940s show that amphetamine combined with task-relevant experience improves postbrain injury behavioral outcomes. Several small clinical trials evaluated the approach as a means of improving poststroke recovery. RESULTS In laboratory studies, the effect of amphetamine on recovery depends on the location and extent of brain injury, the dosi...

Intra-arterial therapy for acute stroke: trials and tribulations.

Intra-arterial therapy (IAT) for acute ischemic stroke has undergone great evolution during the past decade. While intra-venous therapy remains the standard of care for eligible patients, there are those patients in whom IV tPA is contraindicated, or those who fail to improve following IV tPA. In those cases, patients with accessible arterial occlusions may benefit from IAT, especially when rec...

The Trials and Tribulations of CETP Inhibitors

Tenecteplase versus reteplase in acute myocardial infarction: A network meta-analysis of randomized clinical trials

Background: Acute myocardial infarction (AMI) is the leading cause of death throughout the world. One of the standard approaches to treatment of AMI is fibrinolysis. The study was conducted to evaluate the clinical efficacy of tenecteplase versus reteplase through network meta-analysis for AMI. Methods: Randomized trials were comprehensively searched in PubMed, Scopus, Cochrane library, a...

The Trials and Tribulations of Cross - Cultural Research

In press Trials and Tribulations, 2 The Trials and Tribulations of Cross-Cultural Research Those of us who do cross-cultural research usually have a story of precisely when we began our journey into the global territory of research. For some, the interest might have developed at a very young age; for others it might have been happenstance, having stumbled into the field after doing work within ...